Randomized Clinical Trials:

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Controls for Bias and Confounding

Lesson 3 of 5: Controls for Bias and Confounding—Randomization and Blinding

After completing this lesson, you will be able to:

        Explain how chance (random error) might result in an apparent cause-and-effect relationship between the intervention and the outcome.

        Distinguish between the various types of selection bias and information bias that can affect an RCT.

        Discuss the impact of confounding on RCTs.

        Discuss how blinding and randomization can minimize bias and confounding.